パーキンソン病 (PD)
パーキンソン病（PD）は、運動機能に主に影響を及ぼし、主に中高年に発症する一般的な慢性進行性神経変性疾患です。PDは、脳の特定の領域、すなわち中脳黒質のドーパミン作動性ニューロンの著しい脱落と細胞内レビー小体の形成を特徴としています[1]。
PD患者では、SNpc（黒質緻密部）のドーパミン作動性ニューロンが進行性に死亡し（病気の経過で50～70％以上が失われる可能性があり）、線条体のドーパミンレベルが著しく低下して基底核ループのバランスが崩れ（例えば、抑制性伝達物質であるγ-アミノ酪酸（GABA）の機能が相対的に亢進）、最終的に運動症状（振戦、筋硬直、動作緩慢など）が引き起こされます[2]。
正常なα-シヌクレイン（α-synuclein、α-syn）は、主にシナプス前膜に分布し、シナプス小胞の放出とシナプスの維持に関与する可溶性小分子タンパク質です。PDでは、α-synが誤って折りたたまれ（βシート構造を形成）、不溶性線維に凝集し、最終的にレビー小体またはニューライトを形成します。これらは、シナプス機能の破壊などの神経細胞構造に直接的な損傷を与えるだけでなく、プロテアソーム活性の阻害、ミトコンドリア機能の妨害、炎症反応の活性化などの様々な経路を介して細胞死を誘導します[3]。
パーキンソン病の発症機序
パーキンソン病関連抗体
| Target | Catalog# | Product Name | Reactivity | Application |
|---|---|---|---|---|
| α-シヌクレイン異常凝集と播種経路関連抗体： | ||||
| α-synuclein | AMRe01639 | alpha Synuclein Rabbit Monoclonal Antibody | Human,Ratt | WB,IHC-P,IP |
| α-synuclein | AMRe05849 | Phospho-alpha Synuclein (S129) (15T7) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC-P |
| EIF4G1 | APRab10390 | eIF4G Rabbit Polyclonal Antibody | Human,Mouse,Rat | IHC-P,IF-P,IF-F,ICC/IF,WB,ELISA |
| Ubiquitin | AMRe02738 | Ubiquitin Rabbit Monoclonal Antibody | Human,Rat | WB,ICC/IF |
| Ubiquitin | APRab01380 | Ubiquitin Rabbit Polyclonal Antibody | Human | WB,IHC-P,FC |
| Ubiquitin | AMRe21440 | Ubiquitin K48 Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC-F,IHC-P,ICC/IF |
| ミトコンドリア機能障害と酸化ストレス経路関連抗体： | ||||
| Parkin | AMRe15758 | Parkin (17H13) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB |
| PINK1 | APRab04152 | PINK1 Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB |
| LRRK2 | AMRe13444 | LRRK2 (4E1) Rabbit Monoclonal Antibody | Human,Mouse | WB,IP |
| LRRK2 | AMRe13445 | LRRK2 (16M6) Rabbit Monoclonal Antibody | Human,Mouse | WB,IHC-P,ICC/IF,IF-P |
| LRRK2 | AMRe13446 | LRRK2 (6P9) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC-P,ICC/IF,IP,IF-P |
| DJ-1 | APRab09996 | PARK7 (9L2) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC-P,ICC/IF,IF-F,IF-P |
| Nrf2 | AMRe21024 | Nrf2 Rabbit Monoclonal antibody | Human,Mouse,Rat | WB,IHC,IF,IP,ELISA |
| Nrf2 | AMRe03900 | Phospho-Nrf2 (Ser40) Rabbit Monoclonal Antibody | Human,Pig | WB,IHC-P,ICC/IF,FC,IP |
| ATP5F1A | AMRe07325 | ATP5A1 (11Q15) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC-P,ICC/IF,FC,IF-P |
| ATP1B1 | AMRe01696 | ATP1B1 Rabbit Monoclonal Antibody | Human,Rat | WB,IHC-P |
| ATP1A2 | APRab14379 | Na+/K+-ATPase α2 Rabbit Polyclonal Antibody | Human,Mouse,Rat,Monkey | WB,ELISA,IHC-P |
| ATP7A | APRab07343 | ATP7A Rabbit Polyclonal Antibody | Human,Mouse,Rat | IHC-P,IF-P,IF-F,ICC/IF,ELISA |
| ATP6V1C2 | APRab19734 | V-ATPase C2 Rabbit Polyclonal Antibody | Human,Rat,Mouse | WB,ELISA |
| ATP7B | APRab07345 | ATP7B Rabbit Polyclonal Antibody | Human,Mouse,Rat | IHC-P,IF-P,IF-F,ICC/IF,ELISA |
| HTRA2 | AMRe02129 | HtrA2 Rabbit Monoclonal Antibody | Human,Mouse | WB,IHC-F,IHC-P,ICC/IF,IP |
| HTRA2 | AMRe12276 | HTRA2 (8W8) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC-P,IP,IF-P |
| 神経炎症経路関連抗体： | ||||
| HMGB1 | AMRe04024 | HMGB1 Rabbit Monoclonal Antibody | Human, Mouse, Rat | WB,IHC-F,IHC-P,FC |
| HMGB1 | AMRe03744 | HMGB1 Rabbit Monoclonal antibody | Human,Mouse,Rat | WB,IHC-P |
| TLR2 | AMRe18986 | TLR2 (15K3) Rabbit Monoclonal Antibody | Human | WB,ICC/IF |
| TLR4 | APRab08325 | CD284 Rabbit Polyclonal Antibody | Human,Mouse | IF-P,IF-F,ICC/IF,WB,IHC-P,ELISA |
| TNFR3 | APRab13483 | LTβR Rabbit Polyclonal Antibody | Human,Mouse | WB,IF-P,IF-F,ICC/IF,ELISA |
| TNFα | AMM19084 | TNF α(Q34)Mouse Monoclonal Antibody | Human,Rat,Mouse | WB,IHC-P,IF-P,IF-F,ICC/IF |
| TNFα | AMM00896 | TNF alpha (9D9) Mouse Monoclonal Antibody | Human,Rat,Mouse | WB,IHC-P |
| IL-1β | APRab12530 | IL-1β Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA |
| IL-1β | APRab03854 | IL-1 beta Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB |
| IL-6 | APRab03851 | IL-6 Rabbit Polyclonal Antibody | Human | WB,IHC-P,ELISA |
| NLRP3 | AMRe01571 | NLRP3 Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB |
| NLRP3 | AMRe14399 | NALP3 (8Q17) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,FC,IP |
| TREM2 | APRab03407 | TREM2 Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,IHC-P,ICC/IF |
| AKT | AMRe01622 | AKT Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,ICC/IF |
| AKT | APRab01399 | AKT Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,IHC-F,IHC-P,ICC/IF,FC,IP |
| AKT1 phospho T308 | AMRe06740 | AKT1 (5O1) Rabbit Monoclonal Antibody | Human,Mouse | WB,IHC-P,ICC/IF,FC,IP,IF-P |
| AKT1 phospho T308 | AMRe05846 | Phospho-AKT1 (S124) (4J11) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IP |
| AKT1 phospho T308 | AMRe01558 | Phospho-AKT (Ser473) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB |
| Antibodies related to the abnormal function pathway of the protein degradation system: | ||||
| mAChR | APRab13545 | mAChR M4 Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,IF-P,IF-F,ICC/IF,ELISA |
| UCH-L1 | AMRe16043 | PGP9.5 (5O2) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC-P |
| UCH-L1 | APRab19591 | UCH-L1 Rabbit Polyclonal Antibody($99/20μL) | Human,Mouse,Rat | WB,IHC-P,ICC/IF,IF-F,IF-P,ELISA |
| GBA1 | AMRe11321 | GBA (1P9) Rabbit Monoclonal Antibody | Human | WB,IHC-P |
| PTEN | AMRe02494 | PTEN Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB |
| PTEN | AMRe16636 | PTEN (16Q18) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC-P,FC,IP,IF-P |
| MFN2 | AMRe13921 | Mitofusin 2 (8H7) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC-P,ICC/IF,IF-P |
| Other relevant antibodies: | ||||
| PNPLA2 | AMRe01613 | Adipose Triglyceride Lipase Rabbit Monoclonal antibody | Human,Mouse,Rat | WB,IHC-P,IP |
| SQSTM1 | AMRe03796 | SQSTM1/p62 Rabbit Monoclonal Antibody | Human,Mouse | WB,IHC-F,IHC-P,ICC/IF,IP |
| SQSTM1 | AMRe03814 | SQSTM1/p62 Rabbit Monoclonal Antibody | Human | WB,ICC/IF,IP |
| SQSTM1 | AMRe15658 | p62/SQSTM1 (12N5) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,ICC/IF,FC,IP |
| GSK-3β | AMRe03750 | GSK3 beta Rabbit Monoclonal Antibody | Human,Rat,Hamster | WB,IHC-P |
| GSK-3β | AMRe01551 | Phospho-GSK3 beta (Ser9) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC-F,IHC-P,ICC/IF |
| VPS35 | AMRe03255 | ATGL / PNPLA2 (16Z14) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC-P |
ELISA kits
| Target | Catalog# | Product Name | Reactivity | Detection Range | Sensitivity |
|---|---|---|---|---|---|
| TNFα | EH10021 | Human TNF-α (Tumor Necrosis Factor Alpha) ELISA Kit | Human | 7.81-500pg/mL | 4.69pg/mL |
| TNFα | EM27661S | High Sensitivity Mouse TNF-α (Tumor Necrosis Factor Alpha) ELISA Kit | Mouse | 1.56-100pg/mL | 0.93pg/mL |
| IL-1β | EM27654S | Mouse IL-1β (Interleukin 1 Beta) ELISA Kit | Mouse | 3.13-200pg/mL | 1.87pg/mL |
| IL-6 | EM21023S | High Sensitivity Mouse IL-6 (Interleukin 6) ELISA Kit | Mouse | 0.781-50pg/mL | 0.47pg/mL |
| IL-6 | EH10020 | Human IL-6 (Interleukin 6) ELISA Kit | Human | 1.56-100pg/mL | 0.94pg/mL |
| HMGB1 | EH25966 | Human HMGB1 (High Mobility Group Protein 1) ELISA Kit | Human | 6.25-4000pg/mL | 28.3pg/mL |
Related Products
Super-sensitive ECL chemiluminescent reagent
References
Mark JR, Tansey MG. Immune cell metabolic dysfunction in Parkinson's disease. Mol Neurodegener. 2025 Mar 24;20(1):36.[PMID: 40128809].
Dickson DW. Parkinson's disease and parkinsonism: neuropathology. Cold Spring Harb Perspect Med. 2012 Aug 1;2(8):a009258.[PMID: 22908195].
Irmady K, Irmady K, Przedborski S. Progression in Parkinson's Disease. Cold Spring Harb Perspect Med. 2025 Feb 10:a041641. [PMID: 39929733].
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